HOSTING THE IBEC SYMPOSIUM 2023
I was thrilled to host the IBEC symposium where brilliant minds showcased their progress in the scientific field.
My poster:
On the Amyloid-ß transcytosis across the blood-brain barrier
Our group has discovered that the blood-brain barrier (BBB) plays a crucial role in regulating the transport of misfolded proteins to and from the Central Nervous System (CNS). We have found that the BBB controls the trafficking of macromolecular cargo by its affinity towards receptors like the low-density lipoprotein receptor-related protein 1 (LRP1) and the low-density lipoprotein receptor-related protein 8 (LRP8). LRP1 primarily transfers amyloid-β (Aβ) across the BBB, while LRP8 requires further studies. We have developed functionalised polymeric nanoparticles that mimic the in vivo process by having multiple ligand-receptor affinities to encourage this process. These investigations are essential in determining how polymeric nanoparticles can enhance the clearance of Aβ from the CNS, which could lead to the development of novel therapies.
POSTER: download