A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
🚀 Exciting news! My first review as first author, co-written with Giulia Porro, has just been published! 🎉 The article, “A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation,” dives deep into the challenges and cutting-edge strategies for crossing the blood-brain barrier (BBB) to treat CNS disorders. In this review, we explore: - 🧫 The structural and molecular intricacies that govern BBB function - 💉 Current therapeutic approaches leveraging receptor-mediated transcytosis - 🎯 How multivalency enhances nanoparticle specificity and transport across the BBB - 💻 The powerful synergy of computational models with experimental validation to optimise brain drug delivery systems A huge thank you to Cátia Lopes and Giuseppe Battaglia for their invaluable guidance and support throughout this work! I’m thrilled to contribute to advancing this exciting field! You can read the full review here:
Review DOI: here
Review pdf: download